Katie C. Coate is an assistant professor of Nutrition and Dietetics and director of the Master of Science in Nutrition program at Samford University in Birmingham, Alabama. She is also an adjoint assistant professor of Molecular Physiology and Biophysics at Vanderbilt University in Nashville, Tennessee.
Coate received B.S. and M.S. degrees in Nutrition from Auburn University in 2005 and 2007, respectively, and a Ph.D. in Molecular Physiology and Biophysics from Vanderbilt University in 2011. She then completed a postdoctoral fellowship in the Department of Pharmacology and the Howard Hughes Medical Institute at UT Southwestern Medical Center (2011 – 2015). Coate has had a long-standing interest in studying the nutritional and metabolic aspects of obesity, type 2 diabetes, and digestive diseases.
More recently, her research interests have focused on elucidation of the physiologic and molecular mechanisms by which pancreatic cancer triggers exocrine system abnormalities and digestive dysfunction. She hopes to apply this knowledge to the development of novel therapeutic strategies for earlier interception of pancreatic cancer. Coate has also developed teaching expertise in nutrition, integrative physiology, and metabolic regulation, and has established a reputation as an accomplished basic scientist and educator. She is passionate about teaching and mentoring students and young professionals using the talents, skills, and abilities God has gifted her with.
- Ph.D., molecular physiology & biophysics, Vanderbilt University
- M.S., nutrition, Auburn University
- B.S., nutrition science, Auburn University
- Nutrition science
- Metabolic regulation
- Integrative physiology
- Obesity and diabetes
Awards and Honors
Travel Award from the John Templeton Foundation and the University of Alabama at Birmingham to attend the Sackler Colloquium on ‘Reproducibility of Research’ at the National Academy of Sciences, 2017
- Ruth L. Kirschstein National Research Service Award, NIDDK, 2013-2015
- Outstanding Oral Presentation, Boshell Research Day, 2009, 2011
- Charles R. Park and Jackie D. Corbin/Sharon H. Francis Student Travel Award, Vanderbilt University School of Medicine, 2010
- Graduate Student Travel Award, Vanderbilt University Graduate School, 2010
- Travel Grant, European Association for the Study of Diabetes, 2010
- Best Graduate Student Oral Presentation, Vanderbilt University School of Medicine, 2009
- Cellular and Molecular Biosciences Summer Research Scholarship, Auburn University, 2004
- Moore MC, Smith MS, Farmer B, Coate KC, Kraft G, Shiota M, Williams PE, Cherrington AD. Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day. Diabetes. 2018 Jul; 67(7):1237-1245.
- Kraft G, Coate KC, Winnick JJ, Dardevet D, Donahue EP, Cherrington AD, Williams PE, Moore MC. Glucagon’s effect on liver protein metabolism in vivo. Am J Physiol Endocrinol Metab. 2017 Sept; 313(3):E263-E272.
- Edgerton DS, Kraft G, Smith M, Farmer B, Williams PE, Coate KC, Printz RL, O'Brien RM, Cherrington AD. Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion. JCI Insight. 2017 Mar 23;2(6):e91863.
- Coate KC, Hernandez G, Thorne CA, Sun S, Do Ve Le T, Vale K, Kliewer SA, Mangelsdorf DJ. FGF21 is an exocrine pancreas secretagogue. Cell Metab. 2017 Feb; 25:1-9.
- Anderson JG, Ramadori G, Loris RM, Galie M, Berglund ED, Coate KC, Fujikawa T, Pucciarelli S, Moreschini B, Amici A, Andreani C, Coppari R. Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6. Mol Metab. 2015 Sep; 4(11): 846-56.
- Coate KC, Kraft G, Shiota M, Smith MS, Farmer B, Neal DW, Williams P, Cherrington AD, Moore MC. Chronic overeating impairs hepatic glucose uptake and disposition. Am J Physiol Endocrinol Metab. 2015 May; 308(10):E860-7.
- Coate KC, Kliewer SA, Mangelsdorf DJ. SnapShot: Hormones of the gastrointestinal tract. Cell. 2014 Dec; 159(6): 1478.
- Owen BM, Ding X, Morgan DA, Coate KC, Bookout AL, Rahmouni K, Kliewer SA, Mangelsdorf DJ. FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Cell Metab. 2014 Oct; 20(4): 670-77.
- Coate KC, Kraft G, Moore MC, Smith MS, Ramnanan C, Irimia JM, Roach PJ, Farmer B, Neal DW, Williams P, Cherrington AD. Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding. Am J Physiol Endocrinol Metab. 2014 Jul; 307(2): E151-60.
- Saraswathi V, Ramnanan CJ, Wilks AW, Desouza CV, Eller AA, Murali G, Ramalingam R, Milne GL, Coate KC, Edgerton DS. Impact of hematopoietic cyclooxygenase-1 deficiency on obesity-linked adipose tissue inflammation and metabolic disorders in mice. Metabolism. 2013 Nov; 62(11): 1673-85.
- Gifford A, Kullberg J, Berglund J, Malmberg F, Coate KC, Williams PE, Cherrington AD, Avison MJ, Welch EB. Canine body composition quantification using 3 tesla fat-water MRI. J Magn Reson Imaging. 2014 Feb; 39(2): 485-91.
- Coate KC, Smith MS, Shiota M, Irimia JM, Roach PJ, Farmer B, Williams PE, Moore MC. Hepatic glucose metabolism in late pregnancy: normal versus high-fat and –fructose diet. Diabetes. 2013 Mar; 62(3): 753-61.
- Zhang Y, Xie Y, Berglund ED, Coate KC, He TT, Katafuchi T, Xiao G, Potthoff MJ, Wei W, Wan Y, Yu RT, Evans RM, Kliewer SA, Mangelsdorf DJ. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice.Elife. 2012 Oct; 1-14.
- Coate KC, Kraft G, Irimia JM, Smith MS, Farmer B, Neal DW, Roach PJ, Shiota M, Cherrington AD. Portal vein glucose entry triggers a coordinated cellular response that potentiates hepatic glucose uptake and storage in normal but not high-fat/high-fructose-fed dogs. Diabetes. 2013 Feb; 62(2): 392-400.
- Kraft G, Coate KC, Dardevet D, Farmer B, Donahue EP, Williams PE, Cherrington AD, Moore MC. Portal glucose delivery stimulates muscle but not liver protein metabolism. Am J Physiol Endocrinol Metab. 2012 Nov; 303(10): E1202-11.
- Ding X, Boney-Montoya J, Owen BM, Bookout AL, Coate KC, Mangelsdorf DJ, Kliewer SA. βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism. Cell Metab. 2012 Sept; 16(3): 387-93.
- Moore MC, Coate KC, Winnick JJ, An Z, Cherrington AD. Regulation of hepatic glucose uptake and storage in vivo. Adv Nutr. 2012 May; 3(3): 286-94.
- Coate KC, Kraft G, Lautz M, Smith M, Neal DW, Cherrington AD. A High-Fat/High-Fructose Diet Accelerates Nutrient Absorption and Impairs Net Hepatic Glucose Uptake in Response to a Mixed Meal in Partially Pancreatectomized Dogs. J Nutr. 2011 Sept; 141(9):1-9.
- Moore MC, Menon R, Coate KC, Gannon M, Smith MS, Farmer B, Williams PE. Diet-induced impaired glucose tolerance and gestational diabetes in the dog. J Appl Physiol. 2011 Feb; 110(2): 458-67.
- Coate KC, Scott M, Farmer B, Moore MC, Smith M, Roop J, Williams P, Neal DW, Cherrington AD. Chronic Consumption of a High-Fat/High-Fructose Diet Renders the Liver Incapable of Net Hepatic Glucose Uptake. Am J Physiol Endocrinol Metab. 2010 Dec; 299(6):E887-98.
- Coate KC, Huggins KW. Consumption of a High Glycemic Index Diet Increases Abdominal Adiposity but does not Influence Adipose Tissue Pro-oxidant and Anti-oxidant Gene Expression in C57BL/6 Mice. Nutrition Research. 2010 Feb; 30(2):141-50.
- American Society for Nutrition
- American Diabetes Association
- American Physiological Society