Pharmaceutical Sciences Research Institute (PSRI)

The Pharmaceutical Sciences Research Institute (PSRI) offers an alternative to traditional contract research organizations by providing research services in a highly cost effective and timely manner at the highest quality. 


The PSRI offers a broad range of drug discovery and development services focused on the non-clinical setting. Our expertise is centered in dose formulation and bioanalysis across a wide variety of standard and unconventional biomatrices. 

  • Development and validation or transfer of analytical/bioanalytical methodologies in support of non-clinical dose range finding, PK, biodistribution (including CNS penetration), protein binding and various toxicology and safety assessment studies. 
  • Formulation optimization
  • Non-clinical analysis of small molecules and peptides in formulations and biological tissues and fluids. 

We offer comprehensive in-vitro metabolism studies including: 

  • Metabolic stability
  • Metabolite identification
  • CYP450 phenotyping
  • Kinetics
  • Drug interactions

These studies can be customized by the client to support selection of the optimal drug candidate. Studies are conducted in all commercially available non-clinical sub-cellular fractions (e.g., microsomes for phase I and S9 fractions for phase II). 

Major Instrumentation/Software

The PSRI utilizes the following instrumentation/software: 
  • AB Sciex API 3000 triple quadrupole and 4000 QTRAP mass spectrometers
  • Shimadzu Prominence LC20A binary high pressure liquid chromatography systems with DAD
  • LIGHTSIGHT 2.1 metabolism software
  • ANALYST 1.5.1 instrument control and data acquisition software
  • MULTIQUANT 2.0 multiple reaction monitoring software
  • Labsolutions Lite 5.5

For more information or to request research, please contact Dr. Greg Gorman

pharmacist in lab with beakers

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Dr. Greg Gorman
PSRI Director